snes had those special chips though for some games like the fx chip and such for yoshi, starfox, and megaman and of course others
I only know of a few. SFX, DSP, and SA-1. So I went
looking around. Looks like you're right. There's quite a few custom chips involved.
Well, according to Wikipedia, there are 71 game titles that use custom chips. Some seem to be safely disregarded and a few might be resolvable, narrowing the potential unavailable list down a bit. With 785 US titles, having less than 10% of the titles unplayable might be an acceptable loss.
But that loss might be assuaged. With the power gain in CPU's since the 90's. Maybe a modern CPU might be able to pull off emulating some of the custom chips on the fly. Meh... I'm just day dreaming. The amount of research into the vast SNES/Famicom library would be near staggering, then the R&D into designing such a cartridge would be.... well, one can probably turn it into a career choice if the economy wasn't taking such a dump.
Reading up on the custom chips, I think I have a better understanding on why the Game Genie never supported the extra 16 pins.