AFAIK, lexan/plexi is available (in the US at least) in standard imperial fractional sizes (1/16, 1/8, etc), so, if you used 3/4" MDF and 1/8" plexi then you could use 7/8" t-molding.
I know that t-mold.com sells 7/8" in smooth black (most common size is 3/4")....
Rich