Don't know of any reason why hot glue would be bad except if you need to get back at the solder point for some reason.
This is probably the major concern.
Don't try to substitute hot-melt adhesive for a good soldering job.
If you have good solder joints, the wires won't break loose unless you move them around enough to actually break the wires. This is where the hot-melt comes in. Hold your wires to the board close to the solder joint, but not on the solder joint.
It will offer the same benefits, plus allow you to fix a problem if one occurs.
RandyT