Bought a new one of these types of drives for my Windows 7 Notebook PC (it originally had 2 200GB drives, now it's a 320GB and a 750GB). It even has a warning about XP and older systems right on the label.
However, I tried it in an external USB drive enclosure, and it worked fine with my XP system and my Home Server (Windows Server 2003, I think) without any patches or running "WD Align". Thinking it was maybe something with the enclosure, I hooked it up directly to the SATA and power cables inside my XP desktop. Everything still recognized and accessed OK.
So maybe Windows actually patched the OSes to overcome this problem. Take into account, you might not be able to install XP onto a drive like this, since the installer and XP itself at first won't be patched.
Also couldn't test with the Home Server, since all my bays are currently occupied in it. But my server has 2.1TB free out of 3.41TB, so I should be safe for a while.
Drive was formatted in Windows 7 when first received, but I don't think that would've changed anything.