Running without vsync enabled should remove audio problems since the app is actually able to time frames at exactly the same refresh rate as the original game instead having the frames tied to the monitor's refresh rate. The only time it's going to work properly with vsync is when you are able to get the refresh rate of your monitor to exactly match the refresh rate of the original game, which doesn't happen all that often under Windows. Pac-Man is ~60.60 fps, not 60 fps, for instance.
Given all that, even if I do run a game at exactly 60 Hz that is original 60 Hz (1942), I still get overflows.