"Most people"? I don't think there are very many of us.

I used a DB37 and the only complaint I have is that it requires more effort than I'd like, but it's not bad (really, I want too much - I'd like it to be easy like plugging in a usb device!). However, I'd think molex would be quite a bit more effort and will only discourage you from swapping panels as time goes on. Swapping takes enough time as it is; you don't want to make it any harder than it needs to be - believe me! My swappable setup is probably about as easy as it gets and I still find myself sometimes avoiding games because I'm too lazy to swap at the time.
As for breaking, I don't think that's an issue at all if you do it right. On the encoder side, I cut a pre-made DB37 in half and ran the individual wires to the encoder, and then attached the cable to the inside of the cab so there is strain relief and therefore no potential reliability issues on that side. And on the panel side I soldered the wire (can't remember off hand if it was 22 or 20 gauge) directly into DB37 connectors with solder cups, and cable tie the wires to the panel. In addition the connector itself has internal strain relief. So bottom line, I am not at all concerned about reliability of my wiring.
Let me know if you need a lead on DB37 stuff.