I think that's not a problem. I have a vertical monitor (though it's a computer crt monitor), and I run both mame and daphne. Mame and misfit mame is probably not any different. Easiest thing to do is to run them in separate lists, but there's a thread here started by SGT (if I recall his name properly) about a hack for running different emulators in one list using a batch file to choose which emulator to run.