I run all the stuff....The only games I am having a problem running are some of the Midway games from the late 90's (Gauntlet Legends, Blitz, etc), but those run poorly on my main system too, so I don't sweat em. I have heard these games work, so I am sure it is just a settings issue....just don't have time farting around with settings right now
I run EasyMAME .106 (not been a big fan of some of the changes they have made lately) and using the Maximus Arcade frontend. I run MAME, Daphne, Visual Pinball, KEGA, ZNES, FCE and Magic Engine without any performance issues at all.