I've done a bit of investigation into using a Prism to display MAME marquee's converted to gif format which the sign can read. It's quite confusing on a number of levels, but here are my conclusions.
The Prism is only a 80x7 LED display with 64 colours (although I can only count 26 in the software that comes with it). Converting marquees dosn't work on this size display, well it works they just look terrible.
I do believe you can get a BetaBrite classic with a 120x16 LED display with 4 colours (a user has created some animated marquee's by hand you can view
here). Unfortunately only 4 colours means there are not enough colours to represent a marquee clearly (using batch conversion anyway).
If there was a 120x16 Prism with 64 colours then the marquee's would probably look okay. I have used ImageMagick to bulk convert the marquees to this size and colour palette but I don't think you can get Prism's in that size. Also the 120x16 BetaBrite seems to be a rare item, the standard sizes for BetaBrite Alpha seems to be 64x16x4, 64x24x4 and 64x32x4 (width x height x colours), and there are probably the same for a 120 width display, although I can find no info on the 120x16 display.
Conclusion: BetaBrites are not suited for Mame marquee's unless you hand make them using 4 colours with the hard to find 120x16 display.
Yep sure looks like USB only
So no virtual COM port software? That would suck. Running the Prism software I get an error message "Display not connected. COM 255", which seems to indicate that they run on virtual COM port 255 (you can have up to 256 virtual COM ports that act like standard serial COM ports). So I still think there must be a virtual COM driver that comes with these signs. I also found a hidden download area on the BetaBrite site that has an ActiveX control for Alpha signs
here. Not sure if the USB communication is delt with by this control.