When I disable my soundcard in the device manager and then start MaLa, I find the following in the MaLa log file:
2006.09.14 17:23:22.78 Error: Object Class: TfrmMain, Object Function: ReplacePattern_selected, Exception Class: EAccessViolation, Exception Message: Zugriffsverletzung bei Adresse 004A188C in Modul 'MaLa.exe'. Lesen von Adresse 00000004
So I would assume that something is wrong with your soundcard installation.