You could run a vertical + horizontal setup off of one computer with a KVM switch.
For multi-monitor games, I believe somebody did it with a two-screen Punch Out! cab. using Windows Extended Desktop (or whatever Microsoft calls it) to spread MAME's picture across two monitors. That setup would also let you play 4-player games, two guys per screen. Or two player games, each with his own screen. Handy if you've got fat friends.
How much space is there inside that thing- ambitious enough to go for a rotating monitor? You'd only need to do it on one side, and you'd get the best of both worlds.
Or, (and here's what I want do do someday) if you want to go for two computers, you could wire both sides as a standalone machine, but also wire the Player2 side through a KVM switch that would switch the video and controls over to the Player1 PC. Then both sides could be running totally different games, except when you want to play a 4-player or multi-monitor game- then you just shut down the Player2 PC, and switch the KVM and you're good to go. Add ope rotating monitor and you've got everything.
Or, you could put a TV in the P2 side, and hook up your PS2, Xbox, ColecoVision, DVD, etc.
Or, you could put a vector monitor and a ZVG unit in the P2 side.
Or, ...
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Edit:
Found the dual-monitor Punch Out thread:
http://forum.arcadecontrols.com/index.php?topic=41788.0Looks like dude didn't actually do it. But it appears it could be done with VGA capable (WG D9200, Betson MultiSync) monitors and a modern dual-display video card pretty easily.