I assume you are doing a full control panel with at least 2 players, with the trackball in the middle?
Are you planning on putting "extra" buttons near the trackball to use with it? I would recommend instead just using the regular buttons for P1 / P2 and don't add any extra redundant buttons near the trackball. Then it works well for lefties and righties to play trackball games, and reduces control panel clutter. If you have at least 2.5"-3" clearance between trackball and buttons, you won't have any issues.
Look through the stickied 'Show us your control panel' post on here to get some layout ideas.
IMO, you can't beat the "Knievel style" layout, with 2 8-way (or U360) sticks, with a 6 or 8 button cluster each, a trackball dead center, and up top (if you have a larger enough CP) a dedicated 4-way stick next to a spinner with a 2 button cluster. That gives you everything you need while keeping things (somewhat) simple looking.
Have fun building!
Cheers.