multiple control sources with xpadder

[Iceman81]

hey guys, i have a question.  On my setup i have a 2 player control panel with 11 buttons per player(including coin start select). 

I recently had my crt tv go bad, and put an LCD in the cabinet.  I wanted authentic, but beggars cant be choosers as I had a spare LCD.  So now that i have 16:9 i wanted to add newer games, but my control panel will not really be ideal for most of them. 

So heres the question.  Can i use xpadder as is with my current control panel, and add 2 more profiles for 2 xbox360 controllers, and have them run simultaneously? and can i even go as far to have them share the same keys as each player, incase someone preferred to play say an NES game with the 360 controller, and not have to reconfigure the emulators?