If you're talking a small vertical panel, then yeah, that might be a bit small. If it's a large vertical monitor (i.e. 42"+ with the ends hidden) then that will work fine, i've done the same.
Some PC games are fussier than others though, i've had some work out of the box with the odd resolution i'm running, whereas others have required one of the 'borderless windows' program to allow it to run windowed full screen (normal full screen doesn't work). Aspect ratio can be tricky though, some work fine out of the box (especially using borderless windows), but as a last resort you can always use Reshade (or one of it's equivalents) which has all sorts of options, including aspect ratio fixes.