Played once in a graduate economics class. Our team got its ass headed to us because we played it aggressively and everyone else decided to work together. Meh.
That professor set up some of my best comedic timing, though. Classmate walks in, and I groan, "oh god, her husband's life is over." I go on to explain to those around me that once your wife has gotten that damned chin length haircut she describes as "easy" and "fun" you're on a trainwreck involving 40lbs, no more make up, and lots of those scalloped collar t-shirts they like to call a "blouse."
Class starts, and out of nowhere, the professor announces, "yeah, my wife cut all her hair off today.... she says it's easy.... and fun.... yeah, so anyway, this game involves resource tiles..."