So I've had this thing running for a while now. It's dead simple to operate. It gets a lot of play; worked my way through RE1, RE: Nemesis, and RE Code Veronica, now working on Dino Crisis for Sega Saturn. We have Mario Parties and Kart tournaments. And I get in some alone time with the Genesis and SNES often enough, along with Road Rash for 3d0.
The annoying downside is that sometimes people will just want to try everything. I personally like to pick a game and play it and really give it a chance.
Not out of any sort of "I'm the boss of gaming" but just through I grab the controller first, I almost always end up being the one to start, select, exit, and shutdown the system. I was working and my wife had a bunch of ladies over. They had a wine-fuelled 5 hour Mario Kart tournament, and no issues getting anything to work. There are no instructions or anything. It made me happy that it was intuitive enough to just turn on and start gaming.