I currently am using John's Arcade layout (awesome btw) on a vertical LCD monitor.I also have Craftymech's scanline generator. My desktop, Mame, and Mala are all using the 640x480 resolution. Because of this, the Mala layout doesn't look sharp because of the scanline generator. MAME looks awesome with the scanlines, though.
Could I keep the 640x480 resolution for MAME but use a different resolution for everything else? That way I could have a crisp Mala menu, and also keep the MAME games looking "classic" as well. This would work great, because the scanline generator only works with 640x480 and 1024x768 resolutions.