The RetroArch interface got an update in October. More user friendly and operates similar to Sony's Cross Media Bar.

I loves me some RetroArch but it can be confusing to set up initially. Retroarch has a lot of depth to it but Lifehacker just did a basic setup tutorial video for those interested in trying it out.
The video is done on a MAC but the steps are the same for a PC. TIP: The 'x' key on your keyboard is the select button in menu system. (The 'z' key is back)
Bonus: When you are done getting everything set up, check out the shaders. They are impressive. Especially the game boy shader.