According to this (
http://www.crazykong.com/pins/MortalKombat.pin.txt) MC has a standard JAMMA speaker setting. I.e one 8ohm speaker.
Two 4ohm speakers in series (don't do them parallel*) makes a total impedance of 8ohm, so that is one way to do it.
You can also go for two 8ohm speakers (higher total impedance is ok. lower total impedance is not), and then be prepared for the MVS setup.
As told before - MVS does not follow JAMMA standards, since it has a stereo output. You have to do some kind of smart switch to be able to change conveniently between the systems.
I'm not sure about CPS2, but doesn't that require an external amplifier?
* Impedance for speakers:
Series: 8 + 8 = 16ohm , 4 + 4 = 8ohm
Parallel: 8 + 8 = 4ohm , 4 + 4 = 2ohm