Yes sir...I replaced a 60-in-1 with an AS board. I actually have two AS boards. I wouldn't have bought the 2nd, but I found a source who had 3 of them for $275 each shipped... still way more than the 60-in-1, but I managed to sell the used 60-in-1 for $170.00 (right before the recent price drop) so I essentially paid $105 more for the AS board.
PROS: Menu is much better than 60-in-1 boards. Sound is better (though still not 100% perfect). High scores are saved (most games...there are a couple that don't - Liberator, Sinistar, Tetris, and one or two more). High score initials are saved. INSTANT ON...amazing how much I like this. Flick the switch...game is up and running. No waiting. You can set the menu to display games in any order you want (must do this as you populate the board). The PAC games have normal and speed mode at the push of a button. Just play to play normal speed...hold down button 1 and it goes in to speed mode. Moon Patrol and Mario Bros play surprisingly well on a Vertical monitor. DONKEY KONG II.
CONS: Much more expensive. The 60-in-1 is a better solution if you are in to the 8-way games as AS only has three 8-way games (Sinistar (which is actually a 49-way game originally), Zaxxon and Super Zaxxon). Not all the sounds are perfect. There are some minor sound bugs (Mappy's extra man sound jacks up if it plays while other sounds are playing), Donkey Kong II can only be uploaded to the board once per update...which means that if you want to re-order your games or add games to the board, you have to flash the memory thereby losing Donkey Kong II and you are ASS OUT until the next update...which really pisses me off frankly (I paid for the damn ROM I should have unlimited access to the damn thing).
I decided to go to the AS board because it supports more trackball games and my Multipede is a primarily trackball cab... instead of the 60-in-1's 4 titles (Centipede, Millipede, Super Breakout, and Arkanoid), the AS board has those 4 plus Crystal Castles (I really enjoy this game), Liberator, Missile Command (which also plays pretty damn good on a vertical monitor), and GridLee.
Right now the 60-in-1's can be had for a little over a hundred bucks... hard to argue $110-$120 vs $379 though... On top of the $379 you need to purchase a 5v power cord for programming and a serial cable. WHY Steve doesn't include these in the price? You tell me. I simply don't understand why Steve hasn't lowered the prices on these units considering he's losing a TON of business to the 60-in-1 boards. A TON. If he lowered the price to $200 or so these boards would fly off the shelf. Of course i am not privy to what Clay is charging him for a board...
Bottom line: If high scores saves, more correct sounds, more trackball games, and/or Donkey Kong II are important to you, get the AS board. If they aren't, save your dough and get a 60-in-1.
PS: Anyone who says Clays board doesn't contain MAME code is smoking some serious crack. The only thing I can think of as to why MAMEDev isn't all over this board like they are the 60-in-1 boards is because Clay is/was a friend/contributor to MAME and the fact they don't sell the ROMs with the boards.