thanks for the plug slsimon!
yeah, romlister will help weed out that stuff, plus you can do things like remove all the games that use a spinner or trackball if you don't have one, and all the mahjongers or anything else you don't want, not to mention monitor orientation and # of buttons, etc.
The "no clones" checkbox is the important one, however, be aware that some clones are the games we're used to (ie, pacman is a clone of puckman) so you may have to add in a few by hand, using mala to do that: switch to your all games list, locate pacman, then right click and add it to your new trimmed down list that romlister generated. I also think some of the clones are kind of fun/interesting, like pacman hearts or gangly man, so don't just blindly nuke them.
(you could also use romlister to give you a mala gamelist of ONLY clones, then play around with those and selectively add them to your favorites list)
It used to be part of the fun in earlier MAMEs to go through all the games by hand and see what's available and what to play, but it now supports so many games that it's an overwhelming task! I'm right now in the process of revamping my vertical cocktail cabinet, and I ended up with ~450 games to check out, and that's without clones! I've been working at it for a couple weeks now and I'm only up into the R's at the moment. I guess that's better than >6000 games to weed out, so yay for romlister.

-jeff!