First of all, there is no GUI in NoNameMAME. As far as I know, the only MAME with a built in GUI is MAME32.
Second, I think that one Act Labs gun will work with any version of MAME. I think you need NoNameMAME or Analog+ to get two guns working.
I don't actually have one of the guns, so I might be wrong about the two gun part. I am thinking about getting on so I have been reading everthing that gets posted about them.