Yes you can either do it via commandline args or just make different MAME ini files for different games.
Say you want pacman to run differently. Just copy mame.ini to pacman.ini and set the ini however you want.
THanks man, that worked. Although i have one issue, i made an Ini for pacman, and it worked great, for pacman. But now when i play the other games that should be using the default MAME ini they are not using it. They are using the pacman ini.....i think.
If i make an ini for each game it seems to work, the rom uses those settings, but then whatever games are left out seem to not use the default ini like i thought they would. Does that just mean i have to make an ini for every single rom?