Agree with this poster. You are overthinking a problem that isn't too big of a problem in the first place. You aren't going to move your machine that often. If you do then you really DON'T want a multipart machine anyway, as the top half is going to be awkward and have most of the weight, and taking it apart is a great opportunity to damage it.
I have moved some ridiculously heavy stuff into and out of my old 2nd floor apartment (which featured a stairwell with a 180 degree turn that made moving anything big tricky), and it was still easier just to get as many helpers as you needed than it was to start taking stuff apart.
Two average guys with no dolly can move a 19" atari cab (they made the heaviest ones) up or down a stairwell with no problem. Those same two guys can move most 25" games with a bit of grunting. Get 2 more helpers and it becomes super easy.
If moving the game is a concern there are 3 things you can do that are all more reasonable than the two piece cabinet.
The first is to make sure the game has places to hold onto (atari failed miserably here).
The second is to build with weight in mind. Use plywood, don't go crazy with internal framing, etc (look at a few real cabinet interiors before you build).
The third is to make it as easy as possible to pull the monitor out, this can subtract a substantial amount of weight in a hurry.
Also, if your control panel sticks out past the sides then it needs to be removable. Try to avoid making the cabinet both too wide and too deep. Ideally it should either be 26" or less in either width or depth. Classic machines tended to be 24" wide and about 30" deep, although many 70s era games reversed those numbers, being wide, but being less than 26" deep.
I built a cabinet with this exact idea in mind. I based my cabinet on a Centipede cabinet's dimensions, and I made the cut in half just below the bottom of the control panel. I then made the upper half 1.5" wider than an actual Centipede so it would slip over the base (it also gave me more room for controls since I did a two-player setup versus the single trackball on Centipede). I also made the cabinet base a few inches taller so there was something to slip into the top. I've attached a picture of a side-view of it put together mid-construction.
But, I will say once I was done this became a bit of a worthless effort. The upper half ends up being so heavy and unwieldy due to the shape and CRT within that it is really difficult to carry around. Overall it was much easier to use a dolly or just have two people carry the arcade around. It all ended up light enough that two people could carry it just fine. The only thing I kind of like about the two halves is I ran T-Molding all around the top half's frame, so there's a bit of a visual belt-line in the sides of the cabinet.