I have a 5 button array on the top tier of my panel, set up in an Asteroids type formation. The left two buttons are my mouse buttons, working in tandem with a U-trak trackball and Optipac. I haven't had any problems with the two mouse buttons acting as proper arcade buttons in any games in MAME.
I
did have to enable the mouse in
all games to make sure the buttons worked; at first I couldn't get them to work in Asteroids (using MAMES32 v112) because the option to enable mouse was greyed out in the Asteroids-specific preferences, but it worked once I enabled it in the control preferences for all games. They work fine for left/right in Golden Tee, for example.
I was a bit hesitant to put the mouse buttons on the left-- the buttons are reversed, as though for someone left-handed-- but putting them on the right meant I would be moving the trackball with my left hand, and that didn't feel right at all. However, once I tried the left-handed buttons, I found that I didn't even have to think about them being reversed. "Left-click" is still the index finger, but for whatever reason, I didn't expect it to feel that natural. And it's perfect for Centipede.
