Well right off the bat, Roadblasters used a 270 degree steering yoke (IIRC). I really never tried those types of driving games with 360 degree wheels so I don't know if it will hinder it or not.
Err, Roadblasters used a yoke that was a cross between a 360 & a 270 wheel: it had physical restrictor to limit the turn, but an optical encoder instead of a pot. Since mame doesn't have a special input type for this, mame treats the input as a dial. This is closer AFA the data signal (read "electronic hardware emulation") is concerned, but not player UI (POT, aka absolute analog, controllers don't translate well to dial, aka relative analog, inputs in mame).

[shrug]
The one problem I can see is finding a 360 wheel with buttons on it. I think Roadblasters would be a drag with the buttons on the panel.
I don't think you'll find a 360 wheel with buttons. Think of it as basically an oversized spinner.
There are a couple ways. Wireless is the easiest; it could be wireless mouse or game controller. You'll need to map accordingly.
But as Dave said, unrestricted turn wheels don't have buttons. In spinners "with buttons", the spinner itself was the button that you pushed or pulled; not sure if you could do that with a wheel without making it feel weak.
..There are different types of driving set-ups so you may have to build a couple of driving set-ups. If you have one type of game in mind (Roadblasters and APB are two different set-ups entirely), you may be happier with a dedicated.
Ditto. Considering RoadBlasters is pretty unique (yoke with buttons on a restricted turn wheel with optical encoder), it will be hard to find a match for it.
