I had to laugh a bit when I stumbled across this topic
As for how nuclear bombs work...who knows, as for how to rotory engines work...who knows,...as for electrons and circuits?
I FREAKIN KNOW!
There is absolutely 100% no reason why running 2, 4, 6, 8 or however many leds around your cabinet off of a 5V or 12V USB port or any other power source on your motherboard/usb ports will do any harm PROVIDED that:
1. You KNOW what voltage is there.
2. You KNOW what the current (Amps) is available.
3. You KNOW what voltage your LED runs at.
4. You KNOW what current your LED consumes.
5. You make SURE that you have your LEDs (and each associated resistor) wired in parallel with your power supply - NOT IN SERIES!
Bottom line is each LED will consume its required current (say 20mA or .020A). When you add up all of your LEDs, it better NOT be more than what's available current wise from that power supply(or USB port). If it is...you will be F%$&d!
No, I'm not a smartass that read it in a book at radio shack (though you could). You could say this is my area of expertise... I did get a degree in Electrical Engineering. 
you know what, dude, you just might not be the only one here in electrical engineering. I took all the way through processor design and transmission lines at the U of I before I opted to use it as a course sequence for a math degree instead, and go into computer graphics. So maybe check and see if you really read something right before ya break out the cannons, huh?
Bottom line is each LED will consume its required current (say 20mA or .020A). When you add up all of your LEDs, it better NOT be more than what's available current wise from that power supply(or USB port). If it is...you will be F%$&d!
No. That's wrong. You drive an LED with a current. If you look at a datasheet for one, you'll see that in its operation range dV is nearly constant for any dI that doesn't burn the thing out. You must provide the correct limitation of current to the LED to keep it from sucking up too much. It doesn't just "consume its 20mA" and neither is it likely to if you drive it directly with a voltage source. I calculated the margin of error for not burning out a voltage driven LED from one bin in Fairchild to be in the hundredths of volts, assuming the device would draw current exactly according to its datasheet.
EDIT: It's even more wrong than I thought, because if the LEDs are in series like they should be if you connect them to 12v, you
don't add up their currents. You calculate the total power consumption, sigma[V*I].
Also, I've done current measurements with IPB and coin door lamps from Happ, and they consume 160mA at 12V. If a USB port could power this, you could run three 160mA devices before being in the red line. Granted you can't plug a 12V lamp into a USB power source because there isn't a 12v pin, but if the 5 or 6v lamps are anything remotely similar, they should work too. I also know of flashlight bulbs that sure as heck aren't drawing 160mA, because they're running on batteries, and they get a bright bulb out of as little as 3v.
And dude with the 8's in his name:
I know how hard a EE degree is to get. So congrats on having one. However, I also know that other people here
don't have one, so you laughing at people for asking questions about ground loops and power consumption is kind of like me lording it over on you for not knowing how to draw a straight line between points in the Poincare model of hyperbolic space, or what the heck I mean when I say that having under-weighted points in a subdivision skinned skeletal system will result in improper results when the root joint translates.
Besides, I knew a lot of EE people in the U of I. I lived for three years in a dorm where 70 percent of residents were EE. They're one of the best schools for that, and I was
frequently helping grad students to actually
build their projects, because while they knew a heck of a lot about theory, they knew nothing when it came down to the actual devices. So don't tell me you know everything just because you have the degree.