Weight was actually a consideration for me. It sounds like a 4x8 sheet of MDF is 110lbs while a 4x8 sheet of plywood is about 65lbs. I know that is REALLY vague, sorry. I'm not sure if that is 5/8 or 3/4, and I'm not sure if the plywood is Pine, Birch, or Oak. Anyway, the weight is relative (if these weights are for 5/8, then 3/4 would be 1/8 higher). If I have roughly 3 sheets of wood plus framing, that makes the cab roughly 325lbs or 200lbs (random rounding). 200 sounds alot more manageable and plywood has less of a chance to break if I clip the edge with the vaccum.
I'm in the Chicago area, and Menards has had 3/4 Oak or 3/4 Birch on sale for 29.99 the last week. Price match that at Home Depot (because they have a 110% price guarantee) and you you can get it for 26.99. Yes! 26.99 for a 4x8 sheet of 3/4" Oak or 3/4" Birch plywood. The normal price at both stores is $39.99.
So if price was not a consideration (lol, MDF is NOT on sale = $25 per sheet), does an Oak or Birch paint as well as MDF?
This is an important issue to me because if I am spending $1200-$1800 on parts for a cabinet (computer, tv or WG monitor, control panel, etc), I really don't care if I spend $150 on Oak Plywood instead of $75 on MDF, if the plywood is going to be lighter and more durable. Hmm, last week I decided to use MDF, but I think I talked myself back into using the plywood.
If you decide on plywood, but are painting it, there is also 3/4 Lauan Plywood (OVL and better grade), 2 sides sanded. Menards also has that for $24.99 this week, but I don't know what the regular price is. That might be a better option if you are painting the cab.