This will work with mamewah, as powermame is only adjusting certain internal features of mame that would have no effect on mamewah. The only thing that would be different is if you have 49 ways and sir poonga's software. You wouldn't need to have mamewah call on it anymore for autoswitching, as it would be a built in feature of mame now instead of an external program. Otherwise, nothing in mamewah would change.