1. MOST printing machines use 4-color process. If they are going to print a "full-color" image, they lazily and cheaply use only 4 colors to reproduce ALL of the colors of the rainbow. Sometimes this provides mixed results. So, in short; "YES" to #1.
CMYK is a subtractive system. As you add more color, it subtracts light... taking you to black. RGB is an additive system as you add color, it adds light... taking you to white. IF you put equal parts of CMYK printing ink together you (roughly) get black. If you add equal parts of RGB light together you get white... that's how the 2 mediums of print versus computer screen work.
Anymore, RGB can be used for printing, but most printers have to convert your colors to CMYK to output them anyway, because they are using 4 ink colors (Cyan, Magenta, Yellow Blac(k)) rather than Red, Blue and Green. If your colors are very vivid with RGB, they will not reproduce as well with actual 4-color printing ink, which can't reproduce vivid colors as well as an RGB photon gun in your monitor (or whatever the technology is).
2. In short; NO to #2. If you are going to print in CMYK, ALWAYS start with CMYK. Keep as few kinks out of your color process as possible. CMYK will never produce high range colors, so if you start with the CMYK color space, it will force you to stay away from those colors that won't output well.
There are, as always, many caveats to this, some "direct to plate" or digital output imagesetters don't seem to be very bothered by bright colors... course, some of them also use a hexachrome process or other 6-12 color process, rather than the traditional 4. If a company isn't outputting to film plates, then they can get away with using more ink colors, and consequently get a more accurate and vivid color output.