Well, my OptiWiz that I have in shelf for long time appears to be dead so I have to find another mouse to test under windows 7:(
But I'm sure that such configuration mouse/OptiWiz with trackball attached works in the past. Either enable rawinput or multimouse in ini file.
Under windows 10 two mouses works with option multimouse. Tested in Star Wars Arcade (pilot + gunner mode).