After much difficulty (mostly self inflicted), I've got the machine functioning. Now, time for tweaking.
For "General Settings==>Video Options" what settings would be recommended? (see image)
16GiB System memory
Xeon E3-1200 v5/E3-1500 v5/6th Gen C
6th-10th Gen Core Processor PCIe Con
ATI Radeon 8450
Makvision M2929D1G 29" High Resolution (800x600) VGA CRT
Windows 10
Attract Mode 2.6.2
MAME .252