@acvieluf: I don't see how this could be used with only one hand. Seems to me that you have to use the thumb on the dpad or the buttons, so you can't do both simultaneously. Also, I'm not a fan of Nintendo. My first console was the PSX, so I don't know any 8/16bit Sega/Nintendo games. Of the seven consoles that I own one is a Nintendo. Guess which one got the least playtime by far.
@jasonbar: How the fonk am I supposed to use this monstrosity with one hand? I truly can't imagine how that works. Also, $350 for one controller? Nowadays, I wouldn't spend that kind of money on a new console.
So, thanks for the suggestions, but I think I'll look for something mouse driven with maybe a few keyboard shortcuts. If I feel daring, I might start playing Baldur's Gate, that should keep me occupied for some time.