If I recall, this one doesn't let you do that at user level at least, though in these cases you should always try to set the desktop at the video mode of convenience, just to see what happens. The game (Chourensha 68000) runs natively at 256 x 256, so it's not like the developer had too many options to display it properly under Windows. In fact, the WIN port should be avoided at all costs -- it's ~10 % faster at 60 Hz (the original scans at ~55 Hz).
Use GM's X-68000 emulation to play it.