For nes, there are some great, I think korean games, like Cobra mission, World of Jurassic, Lethal weapon, some multigame cartridge by Asdler and more. Theres also some homebrew games like Russian rulette.
Im still using fceux because some game with offscreen reload didnt work for me in Mame (tested long ago)
In sms my favourite game its Marksman Shooting. I reached level 20 and I was a little drunk
For Megadrive I use Genesis plus... core in Retroarch
For Snes Snes9x. It seems that late versions supports Macs Rifle too, but I couldn't remove crosshairs, which I succed long ago with v 1.43, I think.