For those that are following along, or wanting to accomplish the same thing. Using a HD 6450 and a R9 380 poses an unexpected problem, the 6450 is a non-GCN card, and the R9 380 is a GCN card, each of which require a specific CRT emu driver. This made installation tricky, after installing the CRT emu 16.2.1 non-gcn driver, I was able to fully get the 6450 working even though my card was identified as a 7xxx series, but once that driver was installed, the monitor attached to the R9 380 went black, I could still see a mouse but that was all. So after some tinkering I found a working combination, first I installed the non-gcn driver, then after that I installed the gcn driver and both cards worked. As it sits right now, this is where I am at. There is a problem with this though, I cannot get the ATI settings to open which causes a problem, this will not allow me to actually enable FreeSync on the R9.
So tonight I am going to do a clean windows 10 install again, and see if I follow this exact path (not the 100 steps I took on the way) if I can access the controls, if so then I have a working configuration. If not, then my plan is to return the 6450, and for a few dollars more grab a R7 240, which should leave me with 2 cards that are both gcn and can use the same CRT emu driver. I will keep this post updated.
On a side note, it turns out the acrade monitor I was purchasing was not a Wells Gardner, it was actually a Beston Imperial (kortek 2914), I am really happy with the purchase but is does have the "purple discoloration" and slight haziness in the top left corner, I see what I can do with that later.