The official gist can be found
here. I will copy and paste the contents here, but please refer to the gist first for any updates in case I forget to update this thread.
Setting up Windows 10 for a MAME based arcade machineTurn off sticky keysWhile on the desktop, open System settings by clicking the windows icon in the taskbar, type "Ease of Access keyboard settings" and press enter.
Under the Sticky Keys category, turn off "Press one key at a time for keybpard shortcuts".
Change the user name (user name is shown during log in)While on the desktop, open an explorer window by clicking the folder icon in the taskbar.
Press the up arrow in the new explorer window to navigate to the desktop folder.
Click the shortcut to the Control Panel.
Click "User Accounts".
Click "User Accounts" (again).
Click "Change your account name" and change it to your arcade machines name or something else suitable.
Personalize the lock screenThis screen can not be hidden, and will be shown with your user name and icon briefly.
While on the desktop, open an Windows Settings by clicking the windows icon in the taskbar, and then the gear icon.
Click on "Personalization" and then "Lock screen".
Click on the drop box under "Background" and select "Picture".
Click on the "Browse" button and select a photo of your liking.
Turn off "Get fun facts, tips, and more from Windows and Cortana on your lock screen".
Disable the boot screenDisabling the boot screen will not only hide it, but speed up the boot process.
While on the desktop, open System Configuration by clicking the windows icon in the taskbar, type "msconfig" and press enter.
Click on the "Boot" tab.
Check "No GUI boot" and "Make all boot settings pernament".
Click "Apply".
Click "Yes" in the pop up window.
Click "Ok:.
Click "Exit without restart" so we can continue the guide without waiting.
Automatically log in to your Windows accountWhile on the desktop, open netplwiz by clicking the windows icon in the taskbar, type "netplwiz" and press enter.
Uncheck "Users must enter a user name and password to use this computer".
Click "Apply".
Enter password and password confirmation fields.
Click "Ok".
Click "Ok".
Boot directly into your front endWhile on the desktop, open mmc by clicking the windows icon in the taskbar, type "mmc" and press enter.
Click "File" and then "Add/Remove Snap-in...".
Click "Group Policy Object Editor" option.
Click "Add >" button.
Click "Browse" button.
Click "Users" tab.
Click on the current user you set up to automatically log in.
Click "Ok" button.
Click "Finish" button.
Click "Ok" button.
Navigate the tree in the left pane as follows: Console Root -> Local Computer -> User Configuration -> Administrative Templates -> System.
Double Click "Custom User Interface" in the right pane.
Click the "Enabled" radio.
Enter the file path of your front end in the field under "Interface file name". Params to be passed to the executable may be passed here. For the attractmode front end, be sure to include the param "-c pathToConfigDirectory" to avoid an error.
Click "Apply" button.
Click "Ok" button.
Click "File" and then "Save".
Click "Save" button.
Exit the Policy Editor.
After rebootAfter shutting down and then restarting, the only thing visible process should be the lock screen and then your front end.
Launching ExplorerTo launch Explorer for administrative tasks, press "control + alt + delete".
Click "Task Manager".
Click "More details" button.
Click "File" and "Run New Task".
Type "Explorer".
Click "OK" button.