I've played Nitronic Rush quite a bit. I don't think it'll be playable with a wheel.
Why? The damn cars have wings! There are crazy huge jumps where you need to deploy wings and fly the car to the landing (using rocket boosters too). I don't know how you'd manage aerial flight with a wheel.
You could probably use a wheel's paddle shifters to access the roll left / roll right jets boosters, but the up / down axis would be tricky.